Make the switch to extended PDB IDs and PDBx/mmCIF files – what, why, how
As the PDB (Protein Data Bank) grows, it is running out of 4-character PDB IDs (accession codes you use to […]
The DPC assay for measuring Cr(VI)
The main reason the heavy metal chromium is so toxic is that it’s an oxidant. The hexavalent form of Cr, […]
Derivatization of metabolites for GC-MS via methoximation+silylation
Silylation may sound silly to say, but if you want to make organic acids volatile for GC-MS, it gives you […]
The many “colors” of chromatography, especially TLC
Chromatography literally means “writing in color” because it was originally used to separate colored pigments. Nowadays, chromatography has a number […]
Exciting career update!
Signed! It’s official – I am incredibly excited to announce that I have accepted a tenure-track Assistant Professor of Chemistry […]
Reasonableness checks
Before you use your calculator (or even your pencil), use your brain! Silly errors are easy to make when doing […]
Nucleophilic acyl substitutions – swapping what’s hooked up to carbonyl C’s
In nucleophilic acyl substitutions you swap out what’s attached to a carbonyl carbon Because oxygen is more electronegative (electron-hogging) than […]
Cool carbonyl chemistry
Much of biochemistry is carbonyl chemistry – so here’s some more about some of why this is and what to call […]
