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The Bumbling Biochemist

The Bumbling Biochemist

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Author: Brianna Bibel

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Batch binding with gravity flow chromatography

April 18, 2026April 29, 2026

As for the unsticking, here too I like to take advantage of the gravity flow format to try to get […]

Types of scientific papers: What’s what and how to know

April 2, 2026April 2, 2026

The 2 main types of scientific papers are research articles and review articles More on reading scientific articles: https://youtu.be/zRZtK1uB-Fc  ⠀blog […]

Conservation of protein sequences: “conserved” vs. “conservative” (substitutions)

March 31, 2026March 31, 2026

Don’t confuse “conserved” with “conservative” – no, I’m not getting political on you. Instead, I’m talking about the makeup of […]

Bespoke . . . synthesis, treatments, assays, etc.

March 28, 2026March 28, 2026

Increasing numbers of “bespoke” treatments are found these days as gene therapies and cell therapies start hitting the market.  Often […]

Translational readthrough of PTCs (premature termination codons), suppressor tRNAs (sup-tRNAs), and PERT

March 22, 2026March 22, 2026

Primary (research) article for PERT: Pierce, S. E.; Erwood, S.; Oye, K.; An, M.; Krasnow, N.; Zhang, E.; Raguram, A.; Seelig, […]

Orthogonal methods/techniques

March 21, 2026March 21, 2026

Mass Photometry

March 16, 2026March 16, 2026

Off-target and on-target activity & effects

March 3, 2026March 3, 2026

On-target activity/on-target effects: A molecule designed (or at least theorized) to bind one thing, the “target” (e.g., a drug binding […]

Be legendary! Scientific figures & legends, a practical guide

March 1, 2026March 1, 2026

Figures are core to scientific papers. (And they’re often freely accessible even when the paper isn’t). You can learn a […]

Unintentional error: Avoiding common experimental artifacts (especially batch & positional effects)

February 22, 2026February 22, 2026

Although outright fraud and research misconduct definitely does occur in science sometimes, many “reproducibility” problems in science stem from poor […]

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