Formaldehyde protein/nucleic acid & protein/protein crosslinking biochemistry
Formaldehyde is able to form crosslinks between proteins and proteins and proteins and nucleic acids (DNA and RNA). This makes […]
Protein-protein crosslinking – an overview with emphasis on structural biology uses
I’m crossing protein-protein crosslinking off of my biochemistry bucket list. And thought I’d share what I’m learning. So if you’ll […]
Protein structure representations: thank Jane Richardson for ribbon diagrams!
Next time you see a pretty protein structural model displayed in “ribbon diagram” representation, thank Jane Richardson! She invented the […]
Understanding x-ray crystallography structures
X-ray crystallography is a technique where we look at protein (or other molecules’) atomic structures (where the different individual carbons, […]
Protein structural prediction software – just my rambling thoughts & how you can play around with it
People keep asking me about my thoughts on protein structure prediction so I rambled them out. I don’t know the […]
ChimeraX’s webcam feature means you & your protein can feature together in a movie!
I found a new use for lab tape! (And a way to virtually play with proteins like we were together […]
Let’s a-go meet Ago! Argonaute, RNAi, and how structural biology helps us spy!
I love Argonaute, I kid you not! So I hope you don’t get tired of me telling you about this […]
Say hi to PyMol: getting familiar with this molecular visualization software
You know those super pretty “pictures” of proteins that you see in journals and stuff? A lot of them were […]
Cryo-EM – a bumbly intro
The Olympic pictogram chart reminded me of a 2-D class averages figure (more on what this is in a minute) […]
Vitrification – all the supercool kids are doing it: cryoprotectants and flash freezing
At the end of a protein purification, you often are really exhausted and want to take a nap – but […]
