I love Argonaute, I kid you not! So I hope you don’t get tired of me telling you about this awesome protein that is responsible for helping regulate the levels of thousands of proteins throughout your body through RNA interference (RNAi). I can’t show you my unpublished work on it but I can show you what we already know about it. So let’s go look at Ago and how we can learn about how it functions by looking at it as it works! 

structures:

guide-only: 4f3t, Elkayam et al., Cell, 2012, 10.1016/j.cell.2012.05.017 ; https://www.rcsb.org/structure/4f3t 

seed-only target: 4w5r, Schirle et al., Science, 2014, 10.1126/science.1258040; https://www.rcsb.org/structure/4W5R

seed+supplementary target: 6n4o, Sheu-Gruttadauria et al., EMBO J, 2019, 10.15252/embj.2018101153 ; https://www.rcsb.org/structure/6N4O 

more about RNAi: https://bit.ly/awesomeAgo 

more about x-ray crystallography: http://bit.ly/xraycrystallography2 

more about the PDB: https://bit.ly/pdbstructures 

more about PyMol: https://bit.ly/pymolintro & https://bit.ly/pymolmovies 

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