People keep asking me about my thoughts on protein structure prediction so I rambled them out. I don’t know the details of how they work, and go into as much background as usual and use some jargon, but if this is of interest to anyone – here you go. If not, sorry for junking up your feed!

Here’s a good article explaining the situation: https://www.sciencemag.org/news/2021/07/researchers-unveil-phenomenal-new-ai-predicting-protein-structures 

also see: https://science.sciencemag.org/content/373/6557/835 for the importance of the PDB

links for the David Baker lab’s Rosetta/robetta: 

server: https://robetta.bakerlab.org/ 

paper: https://science.sciencemag.org/content/373/6557/871 

links for AlphaFold:

database: https://alphafold.ebi.ac.uk/ 

paper: https://www.nature.com/articles/s41586-021-03819-2 

past posts that might help:

more about x-ray crystallography: http://bit.ly/xraycrystallography2  

more about cryoEM: https://bit.ly/cryoEMbumblyintro 

more about the PDB: https://bit.ly/pdbstructures  

more about PyMol: https://bit.ly/pymolintro & https://bit.ly/pymolmovies 

more about Ago: https://bit.ly/agostructurestuff  

more about all sorts of things:  #365DaysOfScience All (with topics listed) 👉 http://bit.ly/2OllAB0 or search blog: https://thebumblingbiochemist.com   


      

Leave a Reply

Your email address will not be published.