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The Bumbling Biochemist

The Bumbling Biochemist

on a mission to make biochemistry fun and accessible to all

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Author: Brianna Bibel

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Labbing (and teaching) at a small undergrad college (as opposed to a research-intensive institution)

July 5, 2023January 24, 2026

People have asked me if I will miss the lab and the truth is one of the reasons I’ve wanted […]

Prof Bri’s “Office Hours”

July 3, 2023July 5, 2023

I have an office! And, in addition to physical office hours for my students here at St. Mary’s College of […]

Step up to the microplate! But which one?

June 28, 2023June 30, 2023

The colors aren’t just to look stylish… Some plates have transparent bottoms but opaque sides – these can be used […]

Practical Python Practice Problems for People who Pipet

June 27, 2023June 27, 2023

Learning to code is much more fun – and useful – if you practice with things that are practical for […]

Tips for increasing your PCR specificity (decreasing nonspecific product formation)

June 25, 2023June 25, 2023

When it comes to PCR, the thing I typically care most about is specificity. I want my sequence of interest […]

Practical advice for increasing your PCR product yield

June 24, 2023June 24, 2023

If you need more PCR product, it might be tempting to just increase your PCR reaction volume (e.g. double everything […]

The meanings and uses of “apo,” “holo,” & “complex” and structural strategies for getting a look at macromolecular complexes

June 21, 2023May 25, 2026

apo: a poor molecule going solo!The “apo” form of a molecule (typically a protein) is that molecule by itself, not […]

What “cognate” means in biochemistry, especially in the context of translation and cognate tRNAs

June 18, 2023June 18, 2023

“Cognate” (in the context of biology) basically means “correct” – when you see it, think “recognize” because molecules are able […]

Oligo-, poly-, and “oligos”

June 16, 2023June 16, 2023

If someone refers to “an oligo” they’re usually talking about an oligonucleotide (a short nucleic acid (DNA or RNA) chain), […]

Strategies for staying organized with your cloning and plasmids

June 14, 2023June 14, 2023

It’s really important to keep your cloning and plasmids organized – take it from someone who’s literally juggled nearing 2 […]

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