Did you know mitochondria have their own ribosomes?! They only use these them to make 13 proteins, but they’re important ones! Ones we need for making ATP through the electron transport chain. 

Mitochondrial ribosomes (aka mitoribosomes) are smaller than our cytosolic ones (aka cytoribosomes), and smaller than bacterial ones, but they have more proteins. Speaking of bacteria, since mitochondria are derived from an ancient cell swallowing a prokaryotic cell, mitochondrial ribosomes are more “prokaryote-like” than our cytosolic ones are. And this can have important medical consequences because some bacterial ribosome-targeting antibiotics can also bind to and mess up the workings of mitochondrial ribosomes. This is especially an issue if people have sensitizing mutations in their mitochondrial rRNA (ribosomal RNA) that makes it more “bacteria-like” and susceptible to antibiotic-induced hearing loss. 

I don’t have time to write my own text for today, but check out the graphics & video & if you want to know more, here’s a great review:

Structure and Function of the Mitochondrial Ribosome. Basil J. Greber and Nenad Ban. Annual Review of Biochemistry. 2016 85:1, 103-132 https://doi.org/10.1146/annurev-biochem-060815-014343

really helpful site from The Ban Lab: with a guide to ribosome nomenclature – all those u’s, e’s, S’s, m’s, etc… & conversions between different names – plus parts that are conserved, not concserved, etc. Cool stuff. https://bangroup.ethz.ch/research/nomenclature-of-ribosomal-proteins.html

random cool stuff about ribosomes:  https://bit.ly/rad_ribosomes 

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