How does peptide bond formation really happen? Like biochemically, not just in-a-lab-by? If you were one of those people like me who got frustrated/disappointed when in o-chem they teach you it’s a condensation/dehydration reaction and then say – but that’s not how it really happens in your body, this video is for you!

No new text, but I have lots more about translation here: blog form (also has static figures):  https://bit.ly/proteintranslationwedding ; video:  https://youtu.be/L7AKk9X7GDY

And sorry for the bad cinematography – I was balancing my phone on a box…

for more information – here are some scientific articles I got info from and a couple websites

Peptide Bond Formation Mechanism Catalyzed by Ribosome
Katarzyna Świderek, Sergio Marti, Iñaki Tuñón, Vicent Moliner, and Juan Bertran
Journal of the American Chemical Society 2015 137 (37), 12024-12034
DOI: 10.1021/jacs.5b05916 https://pubs.acs.org/doi/abs/10.1021/jacs.5b05916

Mechanism of peptide bond synthesis on the ribosome
Stefan Trobro, Johan Åqvist
Proceedings of the National Academy of Sciences Aug 2005, 102 (35) 12395-12400; DOI: 10.1073/pnas.0504043102 https://www.pnas.org/content/102/35/12395

pH-sensitivity of the ribosomal peptidyl transfer reaction dependent on the identity of the A-site aminoacyl-tRNA
Magnus Johansson, Ka-Weng Ieong, Stefan Trobro, Peter Strazewski, Johan Åqvist, Michael Y. Pavlov, Måns Ehrenberg
Proceedings of the National Academy of Sciences Jan 2011, 108 (1) 79-84; DOI: 10.1073/pnas.1012612107 https://www.pnas.org/content/108/1/79

Protein Synthesis on the Ribosome. (2019, May 20). University of Minnesota Morris. https://chem.libretexts.org/@go/page/151215

Western Oregon University ch450 and ch451: biochemistry – defining life at the molecular level https://wou.edu/chemistry/courses/online-chemistry-textbooks/ch450-and-ch451-biochemistry-defining-life-at-the-molecular-level/chapter-11-translation/

more about all sorts of things: #365DaysOfScience All (with topics listed) 👉 http://bit.ly/2OllAB0 or search blog: http://thebumblingbiochemist.com         

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