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The Bumbling Biochemist

The Bumbling Biochemist

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Category: covid

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The biochemistry of COVID tests – an overview of PCR & antigen tests

January 16, 2022January 16, 2022

When it comes to COVID tests, there are 2 main types – “PCR tests” and “antigen tests.” PCR tests look […]

The biochemistry of rapid COVID-19 antigen tests

January 9, 2022January 14, 2022

Ever wonder how rapid antigen tests work? Firstly, Do NOT confuse this with an antibody test! Finding a viral antigen […]

The basics & biochemistry of Paxlovid (Pfizer’s covid pill, which is an MPro inhibitor)

November 6, 2021November 6, 2021

If you heard about Pfizer’s new COVID *pill* and wondering what it is… it’s an inhibitor of the coronavirus main […]

How rapid coronavirus tests work (ID NOW, antigen, etc.) – The biochemistry for geeks like me

August 3, 2021August 3, 2021

Yesterday’s talk was for people like my dad who just want a brief overview. Today’s talk is for geeks like […]

Types of coronavirus tests – the Cliff’s notes version – molecular, antigen, antibody, etc.

August 2, 2021August 2, 2021

For those who just want a quick-ish explanation with a bit of detail. If you want a long-ish explanation with […]

How coronavirus tests work (the classic RT-PCR ones)

July 30, 2021July 30, 2021

Classical “molecular tests” for “the coronavirus” (SARS-CoV-2), use what is called Reverse-Transcriptase Polymerase Chain Reaction (RT-PCR), to detect SARS-CoV-2’s genetic […]

Neutralizing antibody biochemistry – what they are, why they’re awesome, and how they’re tested for

July 29, 2021August 15, 2021

Antibodies are little proteins that specifically bind viral parts, such as viral proteins, like the spike protein. When someone’s infected, […]

Coronavirus Spike (S) protein biochemistry part 2: cleavage sites, glycosylation, and binding (receptor & antibody)

July 28, 2021August 15, 2021

As promised, here’s part 2 of my talk on the coronavirus Spike (S) protein biochemistry. I go into cleavage sites, […]

Coronavirus Spike (S) protein biochemistry part 1: intro, domains, etc.

July 27, 2021July 28, 2021

I found I had more to say about Spike biochemistry, so here it is… Well, here the first part is. […]

Proline performs big-time! Proline-based stabilization of coronavirus Spike proteins

July 25, 2021July 25, 2021

I’ve been watching Olympic gymnastics which has me thinking about flexibility which has me thinking about the most inflexible amino […]

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